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| 1916 | Began as Nippon Kayaku Seizo Co., Ltd., the first industrial explosives manufacturer in Japan (headquartered at 1-1 Yuraku-Cho, Kojimachi-Ku, Tokyo). Established Teikoku Senryo Seizo Co., Ltd. |
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| 1917 | Obtained permission for production and operations, and started manufacture of explosives at the Asa plant, Yamaguchi Prefecture.
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| 1922 | Listed on the Tokyo Stock Exchange. |
| 1931 | Founded Yamakawa Seiyaku Co., Ltd. began marketing Aspirin the following year.
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| 1934 | Acquired Nippon Fuse, Nippon Detonator, and Chugai Detonator Co., Ltd. |
| 1943 | Acquired Teikoku Senryo Seizo Co., Ltd. and Yamakawa Seiyaku Co., Ltd. |
| 1945 | Founded Hokuyo Explosives Co., Ltd. Changed company name to Nippon Kayaku Co., Ltd. |